题目：Mutational signatures in human cancer

报告人：朱容教授 （北京理工大学）

摘要：This is a science communication report focusing on mutational signatures, the distinct combinations of mutation types generated by different mutational processes. Cancer is often driven by somatic mutations, and understanding these mutations is crucial for unravelling the mechanisms of cancer development. In this report, I will introduce the concept of DNA mutations, explain how mutation catalogues are constructed, describe methods for extracting mutational signatures, and explore the mechanisms underlying these signatures. Additionally, I will introduce the applications and recent advances in mutational signature research. By examining mutational signatures, this report aims to shed light on how genomic mutation data from cancer patients can be used to quantify DNA mutational processes and patterns, offering deeper insights into the biological processes driving cancer. This understanding paves the way for advancements in cancer diagnosis, prognosis, and personalised treatment strategies.  

报告人简介：Dr. Rong Zhu graduated from the Academy of Mathematics and Systems Science at the Chinese Academy of Sciences and later conducted research at Newcastle University and the University of Cambridge in the UK. Her research interests include model averaging, model selection, high-dimensional statistics, and genomic data modeling. She has published several academic papers in top international journals such as the Journal of the American Statistical Association and Journal of Business & Economic Statistics.  

报告时间：2024年12月18日（周三）下午16:00-17:00  

报告地点：教二楼727  

联系人：邹国华